Biohub ESM
Chan Zuckerberg Biohub, Inc. · Scientific Research
Biohub ESM helps you understand proteins from a name, sequence, or file: explore mutation landscapes, interpret what ESMC sees, predict and view all-atom structures, and discover related proteins. It chooses the right ESM workflow, preserves confidence and provenance, and presents results automatically. It also supports MSA-guided and modified-complex workflows, and private or large-scale compute routing. Supported protein sequences use the Biohub MCP viewer. Complexes and exact prediction files use a separate molecular viewer when available, with an agent-generated static rendering as a last resort where local rendering tools are available. Managed inference requires a Biohub API key and may incur usage charges. Predictions support research hypotheses, not experimental conclusions.
Rankings
Skills
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Starter prompts
- Map the mutational landscape of PETase and show me where it is most constrained or tolerant.
- Show me what ESMC has learned about ATP synthase and map the strongest features onto its structure.
- Model how a modified GLP-1 peptide with a lipid linker might engage GLP-1R, then show me the complex.